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What Are the Different Types of Clinical Trials - PaidClinicalTrials.org |
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What Are the Different Types of Clinical Trials - PaidClinicalTrials.org |
What Are the Different Types of Clinical Trials?
There are several different types of clinical trials.
* Prevention trials help doctors determine whether particular medications, vitamins, or other treatments lower the risk of developing a disease, such as lung cancer.
* Screening and diagnostic trials look for better ways to detect and accurately identify diseases.
* Quality of life trials look for ways to improve the comfort of patients. For example, this type of trial might provide new ways to prevent nausea and vomiting caused by chemotherapy.
* Treatment trials test the effectiveness of new drugs and treatments compared to those that already exist.
Treatment clinical trials are almost always conducted in a series of three steps, called phase 1, phase 2, and phase 3 clinical trials.
Phase 1 clinical trials focus on the safety and side effects of the trial drug. They usually enroll only a small number of volunteers. The first volunteers receive a low dose, to see how well they can tolerate the drug.
The dose is increased a little at a time over the course of the trial so that researchers can learn how the drug acts inside the body, the maximum safe dosage, and possible side effects. The maximum safe dosage is used for later studies.
A phase 2 clinical trial is larger study that helps researchers to learn more about the drug, how the body uses it, and the drug’s effectiveness. Depending on the success of the tested drug or treatment, some participants benefit from the treatment received in a phase 2 study.
If a drug or treatment looks promising in phase 1 and 2 trials, it moves on to a phase 3 clinical trial. In a phase 3 trial, researchers compare a new drug to the current standard treatment for the condition being studied. This type of clinical trial helps researchers figure out the best way to use the new drug.
Phase 3 trials are usually conducted at multiple locations and include large numbers of volunteers. Sometimes, a drug or treatment also goes through a phase 4 clinical trial to evaluate its long-term safety and effectiveness.
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