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Trial of BIBW 2992 Plus Weekly Paclitaxel Versus Investigator's Choice of Single Agent Chemotherapy Following BIBW 2992 Monotherapy in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib

Condition: Carcinoma, Non-Small-Cell Lung
Interventions: Drug: BIBW 2992; Drug: Investigator´s choice of chemotherapy
Sponsor: Boehringer Ingelheim Pharmaceuticals
Recruiting - verified March 2010
Clinical, Molecular and by Neuroimaging of LRRK2 Mutations

Condition: Parkinson's Disease
Intervention:
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified March 2010
Nucleipark:High Field MR Imaging (7T and 3T) of the Brainstem, the Deep Nuclei and Their Connections in the Parkinsonian Syndromes. Applications to Prognosis, Pathophysiology and Improvement of Therapeutic Strategies

Conditions: Parkinson's Disease; MRI
Intervention: Other: 3T and 7T MR imaging
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting - verified March 2010
A Study of Immunotherapy With TIL (Tumor Infiltrating Lymphocytes) in Combination With Intra-tumoral Injections of Interferon Gamma-adenovirus (Ad-IFNg) in Patients With Stage IIIc or Stage IV Metastatic Melanoma (AJCC)(Protocol TIL-Ad-INFg)

Condition: Metastatic Melanoma
Intervention: Other: TIL-Ad-INFg
Sponsor: Nantes University Hospital
Recruiting - verified March 2010
Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.

Condition: Pain, Postoperative
Interventions: Drug: Ropivacaine + Sufentanil; Drug: Ropivacaine
Sponsor: Hospices Civils de Lyon
Not yet recruiting - verified March 2010
A Pharmaco-epidemiological Study of Short Patients Born Small for Gestational Age (SGA), Treated With Saizen® (Recombinant Somatropin)

Condition: Infant, Small for Gestational Age
Intervention: Drug: recombinant somatropin
Sponsor: Merck KGaA
Recruiting - verified March 2010
Phase II Trial of AUY922 vs. Comparators in Advanced Gastric Cancer

Conditions: Advanced Gastric Cancer; Gastro-esophageal Junction Cancer
Interventions: Drug: AUY922; Drug: Docetaxel or Irinotecan
Sponsor: Novartis Pharmaceuticals
Not yet recruiting - verified March 2010
An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours

Condition: Postoperative Pain
Interventions: Drug: Morphine 6-glucuronide; Drug: Morphine
Sponsors: Paion UK Ltd.; Chiltern International Ltd.; HFL Ltd.
Completed - verified March 2010
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity

Conditions: Liver Fibrosis; Liver Cirrhosis; Viral Hepatitis; Liver Tumour; Cardiac Failure; Biliary Cholestasis.
Interventions: Device: ARFI measurement; Device: ARFI measurement; Device: ARFI measurement
Sponsor: University Hospital, Bordeaux
Not yet recruiting - verified March 2010
Effectiveness of Care Management in Alzheimer Patients

Conditions: Alzheimer Disease or Associated Disorder; Mild to Moderately Severe Dementia
Intervention: Other: Intervention of the social worker
Sponsor: Institut de Sante Publique, d'Epidemiologie et de Developpement
Recruiting - verified March 2010
Effect of Deep Brain Stimulation on Gastrointestinal (GI) Motility

Condition: Parkinson's Disease
Intervention: Device: Deep brain stimulation
Sponsor: University Hospital, Rouen
Recruiting - verified March 2010
Neurotrophins Implications in Primary Sjögren Syndrome

Condition: Primary Sjögren Syndrome
Intervention: Biological: blood sample
Sponsor: University Hospital, Limoges
Recruiting - verified March 2010
Feasibility of Critical Flicker Frequency Procedure for the Diagnosis of Minimal Encephalopathy

Condition: Cirrhosis
Intervention: Other: Critical flicker frequency procedure
Sponsor: University Hospital, Toulouse
Recruiting - verified March 2010
Ephrin B1 Regulation in Human Right Appendage

Condition: Cardiac Diseases
Intervention:
Sponsor: University Hospital, Toulouse
Not yet recruiting - verified March 2010
Temsirolimus in Treating Patients With Advanced Liver Cancer and Cirrhosis

Condition: Liver Cancer
Interventions: Drug: temsirolimus; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: quality-of-life assessment; Radiation: fludeoxyglucose F 18
Sponsor: Federation Francophone de Cancerologie Digestive
Recruiting - verified March 2010
Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM.

Conditions: Monoclonal Gammopathy of Undetermined Significance; Smoldering Myeloma
Intervention: Genetic: Genetic study of DNA copies
Sponsors: Rennes University Hospital; Intergroupe Francophone du Myelome
Recruiting - verified March 2010
Progression of Renal Interstitial Fibrosis / Tubular Atrophy (IF/TA) According to Epithelial-mesenchymal Transition (EMT) and Immunosuppressive Regimen (Everolimus Based Versus CNI Based) in de Novo Renal Transplant Recipients

Condition: Renal Interstitial Fibrosis
Interventions: Drug: Everolimus + enteric-coated mycophenolate sodium + Steroids; Drug: Cyclosporine A+EC-MPA+steroids
Sponsor: Novartis
Recruiting - verified March 2010
French Observatory of Acute Heart Failure

Condition: Acute Heart Failure
Intervention: Other: No intervention, observational study
Sponsor: French Cardiology Society
Active, not recruiting - verified December 2008
Electrical Stimulation to Recover Greater Range of Motion After Surgery

Condition: Thumb Joint Stiffness
Intervention: Other: electrically induced muscle activation
Sponsor: Université Joseph Fourier
Completed - verified February 2010
Magnetic Resonance Diagnosis of Pulmonary Embolism

Conditions: Lung Diseases; Pulmonary Embolism
Intervention: Procedure: Gadolinium-enhanced Magnetic Resonance Imaging
Sponsor: Assistance Publique - Hôpitaux de Paris
Terminated - verified March 2007
A Study of a Remediation Program of Social Cognition in Schizophrenia

Condition: Schizophrenia
Intervention: Behavioral: original cognitive therapy
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified February 2010
Polyacrylamide Hydrogel Injection in HIV-related Lipoatrophy

Conditions: HIV Infection; Antiretroviral Side Effects; Lipodystrophy Syndrome Related to HIV Infection
Intervention: Device: Eutrophill
Sponsor: Assistance Publique - Hôpitaux de Paris
Completed - verified January 2010
Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia

Condition: Pain, Postoperative
Interventions: Drug: continuous ropivacaine preperitoneal infusion; Drug: intravenous lidocaine infusion; Drug: parenteral analgesia combining acetaminophen and morphine; Drug: NaCl
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified February 2010
High Volume Veno-venous Hemofiltration Versus Standard Care for Post-cardiac Surgery Shock

Condition: Shock
Interventions: Procedure: high volume hemofiltration; Procedure: standard care
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified December 2009
Evaluation of the Frequency of Limitation of Activity in Patients With Persistent Asthma

Condition: Persistent Asthma
Intervention:
Sponsor: AstraZeneca
Recruiting - verified March 2010
Observational Registry of Treatment Patterns in Castrate-resistant Prostate Cancer (CRPC) Patients - PORTREAT

Condition: Prostatic Neoplasms
Intervention:
Sponsor: Sanofi-Aventis
Recruiting - verified February 2010
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: NN1250; Drug: insulin glargine
Sponsor: Novo Nordisk
Recruiting - verified March 2010
A Study of the Safety and Efficacy of Ustekinumab in Patients With Psoriatic Arthritis Who Have Prior Exposure to Anti TNF Agents

Condition: Arthritis, Psoriatic
Interventions: Drug: ustekinumab; Drug: placebo; Drug: placebo; Drug: ustekinumab; Drug: ustekinumab; Drug: placebo; Drug: ustekinumab; Drug: ustekinumab
Sponsor: Centocor, Inc.
Not yet recruiting - verified February 2010
Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects

Condition: Obesity
Interventions: Behavioral: training; Drug: nicotinic acid; Drug: Placebo
Sponsor: University Hospital, Toulouse
Recruiting - verified March 2010
Prospective, Multicenter Non Interventional Study to Evaluate Adherence to Betaferon Over a 2 Years Period

Condition: Multiple Sclerosis
Intervention: Drug: Betaseron (Interferon beta-1b, BAY86-5046)
Sponsor: Bayer
Not yet recruiting - verified March 2010
Tezosentan in Pulmonary Arterial Hypertension

Condition: Pulmonary Arterial Hypertension
Intervention: Drug: Tezosentan
Sponsor: Actelion
Recruiting - verified February 2010
Sorafenib Tosylate With or Without Pravastatin in Treating Patients With Liver Cancer and Cirrhosis

Condition: Liver Cancer
Interventions: Drug: pravastatin; Drug: sorafenib tosylate; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Procedure: quality-of-life assessment
Sponsor: Federation Francophone de Cancerologie Digestive
Recruiting - verified February 2010
4965 Post-approval Study

Conditions: Arrhythmia; Heart Failure
Intervention:
Sponsor: Medtronic Cardiac Rhythm Disease Management
Recruiting - verified February 2010
CoreValve Advance International Post Market Study

Condition: Severe Aortic Valve Stenosis
Intervention: Device: Medtronic CoreValve System
Sponsor: Medtronic Bakken Research Center
Not yet recruiting - verified March 2010
Retrospective Palivizumab Study in Children With Hemodynamically Significant Congenital Heart Disease

Condition: Severe Respiratory Syncytial Virus Infection
Intervention:
Sponsor: Abbott
Completed - verified February 2010
Genotropin Treatment in Short Prepubertal Children With Intra-Uterine Growth Retardation

Conditions: Growth Disorders; Intrauterine Growth Retardation
Interventions: Drug: Genotonorm; Drug: Genotonorm; Drug: Genotonorm
Sponsor: Pfizer
Completed - verified February 2010
Cognitive Remediation Therapy and Schizophrenia

Condition: Schizophrenia
Interventions: Behavioral: cognitive remediation therapy; Behavioral: non-CRT
Sponsors: Hôpital le Vinatier; University Hospital, Grenoble; University Hospital, Clermont-Ferrand
Active, not recruiting - verified January 2006
Evaluation of Muscle StO2 as a Prognostic Factor After Out of Hospital Cardiac Arrest

Condition: Cardiac Arrest
Intervention: Other: Vascular occlusion test
Sponsor: Centre Hospitalier Universitaire de Nice
Not yet recruiting - verified February 2010
Phase I Study in RAD 001 Patients With Relapse AML

Condition: AML
Intervention: Drug: RAD 001
Sponsors: Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang GOELAMS; Novartis Pharmaceuticals
Recruiting - verified February 2010
Study Comparing Tutomesh® Repair to Conventional Surgical Techniques in Potentially Contaminated Hernia Repair and Abdominal Wall Reconstruction

Conditions: Potentially Contaminated Hernia Repair; Potentially Contaminated Abdominal Wall Reconstruction
Interventions: Procedure: Conventional technique; Procedure: Technique Tutomesh®
Sponsor: Centre Hospitalier Régional Universitaire Montpellier
Recruiting - verified February 2010
BF2.649 in Patients With Obstructive Sleep Apnea (OSA), Still Complaining of Excessive Daytime Sleepiness (EDS) and Refusing to be Treated by Continuous Positive Airway Pressure (CPAP)

Conditions: Obstructive Sleep Apnea; Excessive Daytime Sleepiness
Interventions: Drug: BF2.649; Drug: Placebo
Sponsor: Bioprojet
Not yet recruiting - verified February 2010
Auto-immunity in Lupus Patients After Influenza Vaccine

Condition: Systemic Lupus Erythematosus (SLE)
Intervention: Drug: Vaccine
Sponsors: Assistance Publique - Hôpitaux de Paris; Institut National de la Santé Et de la Recherche Médicale, France
Completed - verified February 2010
Study of Pediatric Hepatic Fibrosis

Conditions: Cirrhosis; Liver Fibrosis; Portal Hypertension; Cystic Fibrosis; Parenteral Nutrition
Intervention: Other: Elastometry
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified February 2010
Effectiveness of a French Automated Web-based Smoking Cessation Program : a Randomized Controlled Trial

Condition: Tobacco Consumption
Interventions: Behavioral: Web-based automated "coaching" by e-mails; Behavioral: Self-help guide
Sponsor: Institut national de prevention et d'education pour la sante
Not yet recruiting - verified February 2010
Determination of the Predictive Factors in the Reversibility or the Aggravation in the Disorders of the Glucose Metabolism in Cystic Fibrosis Patients

Condition: Diabetes in Cystic Fibrosis Patients
Intervention: Other: Prospective cohort with an annual follow-up
Sponsor: Hospices Civils de Lyon
Recruiting - verified October 2009
Preventing Malnutrition and Restoring Nutritional Status in Hospitalized Children

Condition: Nutrition Disorders
Interventions: Procedure: Access to a Computerized Clinical Decision Support System (CCDDS); Behavioral: Education of Healthcare workers; Other: Local assistance by a dietician
Sponsor: Hospices Civils de Lyon
Recruiting - verified March 2010
BF2.649 in Patients With Obstructive Sleep Apnea Syndrome (OSA) and Treated by Continuous Positive Airway Pressure (CPAP) But Still Complaining of Excessive Daytime Sleepiness (EDS)

Conditions: Obstructive Sleep Apnea; Excessive Daytime Sleepiness
Interventions: Drug: BF2.649; Drug: modafinil; Drug: Placebo
Sponsor: Bioprojet
Not yet recruiting - verified February 2010
Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/Maintenance Treatment in Young and Elderly Patients : 3 Randomized Studies.

Condition: Multiple Myeloma de Novo Treatment
Interventions: Drug: Thalidomide, Dexamethasone; Drug: Vincristin , Adriamycin, Dexamethasone = VAD; Drug: Thalidomide, melphalan, endoxan, dexamethasone (MCDex-Thal); Drug: melphalan, endoxan, dexamethasone (MCDex); Drug: Thalidomide, Dexamethasone
Sponsors: University Hospital, Caen; Laphal
Completed - verified February 2010
Validation of Dyskinesia Rating Scales

Condition: Parkinson's Disease
Interventions: Drug: Amantadine; Drug: Placebo
Sponsors: Rush University Medical Center; Michael J. Fox Foundation for Parkinson's Research
Recruiting - verified February 2010
Combined Versus Successive Macular Hole and Cataract Surgery

Conditions: Macular Hole; Visual Acuity
Intervention:
Sponsor: Centre Hospitalier Universitaire Dijon
Completed - verified January 2006
Effect of Countermeasures on Nocturnal Driving Performance

Condition: Sleepiness
Interventions: Other: Real driving situation; Other: Driving simulator
Sponsors: University Hospital, Bordeaux; ERANET; INSERM ERI27 Mobilités Cognition et Temporalité; Centre du Sommeil et de la Vigilance - Hôpital Hôtel – Dieu; IMF, CNRS UMR-5231
Recruiting - verified February 2010
Evaluation of the Bonfils Fiberscope for Predicted Difficult Intubation in Awake Patients With Ear, Nose, and Throat (ENT) Cancer (INVIBO)

Condition: Carcinoma
Intervention: Device: Bonfils fiberscope intubation
Sponsor: Centre Leon Berard
Completed - verified February 2010
Potential Benefits of Dietary Advices Alone or Associated to Nutraceutical Food Supplements Argan Oil, VSL#3 Probiotic Blend, 5203-L Fruit Extract Terpene

Condition: Healthy Elderly People
Interventions: Dietary Supplement: VSL#3® probiotic blend; Dietary Supplement: AISA-5203-L fruit extracted terpene; Dietary Supplement: Argan oil; Behavioral: Optimal Diet
Sponsor: University Hospital, Bordeaux
Not yet recruiting - verified February 2010
Mild Therapeutic Hypothermia During Severe Sepsis

Condition: Sepsis
Intervention: Procedure: Mild therapeutic hypothermia induction
Sponsor: University Hospital, Brest
Completed - verified February 2010
An Observational Study on Treatment Compliance by Children Treated With Growth Hormone

Condition: Growth Hormone Deficiency
Intervention: Behavioral: No treatment given
Sponsor: Novo Nordisk
Not yet recruiting - verified February 2010
Transcranial Doppler Ultrasonography and Brain Death

Condition: Brain Dead
Intervention: Other: Transcranial doppler
Sponsor: Institut d'Anesthesiologie des Alpes Maritimes
Recruiting - verified February 2010
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: NN1250; Drug: insulin glargine
Sponsor: Novo Nordisk
Recruiting - verified March 2010

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